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Research Program

Clinical Trials

Psilocybin Therapy for Posttraumatic Stress Disorder

Our pilot study investigates the safety and efficacy of Psilocybin Therapy with or without trauma-focused psychotherapy in the treatment of PTSD.

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Psilocybin and MDMA for PTSD among Military Veterans

Our trial investigates the safety and efficacy of co-administered psilocybin and MDMA in the treatment of posttraumatic stress among US Military Veterans

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Psilocybin versus MDMA-Assisted Therapy for Posttraumatic Stress Disorder

Our forthcoming study will compare the safety and efficacy of Psilocybin Therapy to MDMA-Assisted Therapy for treating PTSD.

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Apply (TBD)

Papers

Index

Psychedelic Therapy & Treatment Mechanisms

Exploring serotonergic psychedelics as a treatment for personality disorders Neuropsychopharmacology

Assessing expectancy and suggestibility in a trial of escitalopram v. psilocybin for depression Psychological Medicine

Effect of psilocybin versus escitalopram on depression symptom severity in patients with moderate-to-severe major depressive disorder: observational 6-month follow-up of a phase 2, double-blind, randomised, controlled trial eClinicalMedicine

Unique psychological mechanisms underlying psilocybin therapy versus escitalopram treatment in the treatment of major depressive disorder International Journal of Mental Health and Addiction

Clinically relevant acute subjective effects of psychedelics beyond mystical experience Nature Reviews Psychology

Psilocybin and other classic psychedelics in depression Emerging Neurobiology of Antidepressant Treatments (book chapter)

A critical evaluation of QIDS-SR-16 using data from a trial of psilocybin therapy versus escitalopram treatment for depression Journal of Psychopharmacology

Psychedelic-induced Personality Change

An investigation of acute physiological and psychological moderators of psychedelic-induced personality change among healthy volunteers Neuroscience Applied

Who are you after psychedelics? A systematic review and a meta-analysis of the magnitude of long-term effects of serotonergic psychedelics on cognition/creativity, emotional processing and personality Neuroscience & Biobehavioral Reviews

Personality change in a trial of psilocybin therapy v. escitalopram treatment for depression Psychological Medicine

Perceptions of psychedelic personality change, determinants of use, setting and drug moderation: Toward a holistic model Journal of Psychedelic Studies

Examining the therapeutic effect of ceremonial ayahuasca on narcissistic personality and antagonistic externalizing in adults Journal of Personality Disorders

Shipibo-Conibo Ceremonial Ayahuasca & Mechanisms

Ayahuasca in the Treatment of Posttraumatic Stress Disorder: Mixed-Methods Case Series Evaluation in Military Combat Veterans Psychological Trauma: Theory, Research, Practice, and Policy

Prevalence and therapeutic impact of adverse life event reexperiencing under ceremonial ayahuasca Scientific Reports

Ayahuasca: A review of historical, pharmacological, and therapeutic aspects Psychiatry and Clinical Neurosciences Reports

Prospective examination of the therapeutic role of psychological flexibility and cognitive reappraisal in the ceremonial use of ayahuasca Journal of Psychopharmacology

Personality & Psychopathology

Ink and Identity: Personality perceptions based on tattoos Journal of Research in Personality

Canalization and plasticity in psychopathology Neuropsychopharmacology

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Dr. Brandon Weiss

About Us

Brandon Weiss, PhD is a clinical psychologist and Assistant Professor at Johns Hopkins University School of Medicine working in The Center for Psychedelic and Consciousness Research. Ten years ago, he began investigating the role of psychedelics in improving mental health and personality, especially for Veterans suffering with posttraumatic stress.

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